Research Article

Mass Spectrometry Amyloid Typing Is Reproducible across Multiple Organ Sites

Table 3

Results of amyloid typing based on the proteomic analysis.

CaseTissueBiological replicatesThe MS/MS counts of the most abundant amyloid proteinsā€‰
Ig kappa chain C regionApolipoprotein EIg gamma-1 chain C regionSerum amyloid P-componentIg gamma-3 chain C regionApolipoprotein A-IVIg kappa chain V-III region SIEIg gamma-2 chain C regionIg kappa chain V-III region VGIg alpha-1 chain C regionApolipoprotein A-IIg lambda-2 chain C regionsGelsolinTransthyretinIg kappa chain V-III region POMFibrinogen alpha chainProteomic typing

1Heart351362019998775544332
Liver3646115335119396762434

2Heart356254101372101292711011
Tongue24417451244001312131402

3Heart3373529153100115221003
Liver334626932610014219010

4Heart3107321316745260312461414
Liver1403312125725038406010

5Heart31212151121001410240
Small intestine320112132385014422252

6Heart37116522911048142714
Liver23166923221136121803

7Heart36207203422104173168010
Liver2315627231100313171603

8Heart351731524011059251406
Kidney31123931453251882941004

9Heart3525512210110210305305
Liver3344628213110313300408

10Heart3102268331040315264304
Kidney313431513614210175325514

11Heart31141703101011302101
Liver314401002400020340209

Italic indicates the most abundant amyloid protein in the sample and underline indicates proteins associated with the amyloid formation.