Research Article

Antitumor Effect of Albendazole on Cutaneous Squamous Cell Carcinoma (SCC) Cells

Figure 6

(a) SCC13 cells were treated with albendazole and tunicamycin at the indicated concentrations for 24 h. Albendazole and tunicamycin induced the ER stress in a dose-dependent manner. (b) Cleavage of PARP-1 and caspase-3 increased significantly by albendazole treatment in SCC13 cells. However, tunicamycin did not induce cleavage of PARP-1 and caspase-3. (c) SCC13 cells and normal human epidermal keratinocytes were treated with albendazole at the indicated concentrations for 24. Albendazole induced ER stress in SCC13 cells but not in keratinocytes.