BioMed Research International / 2019 / Article / Tab 1 / Review Article
Hyposmia as a Predictive Marker of Parkinson’s Disease: A Systematic Review and Meta-Analysis Table 1 Characteristics of the included evidence.
Author Year Country Population Age Gender (M/F) Tevent Tsample Cevent Csample PD diagnosis Hyposmia assessment Follow-up NOS Antje Haehner [32 ] 2018 Germany patients diagnosed with an idiopathic smell disorder at Smell and Taste Clinic from 2000 to 2014 were contacted for a telephone interview. 70.1 ± 11.4 years (range 26–95 years) 216/258 44 406 1 68 NA the “Sniffin’ Sticks” average 8.1 years (range 2–17 years; ± SD 3.75) 9 Alastair J. Noyce [33 ] 2017 UK participants were recruited via the study website following an advertising campaign in 2011 66.2 (63.5-70.5) years 517/806 4 198 3 198 U.K. Brain Bank diagnostic criteria UPSIT 3 years 9 Honglei Chen [34 ] 2017 US 3,075 well-functioning community-dwelling individuals in the metropolitan areas of Pittsburgh, Pennsylvania, and Memphis, Tennessee. 70–79 years 48.4/51.6 (%) 26 764 16 1698 ICD-9-CM BSIT 16 years 8 Stefanie Lerche [35 ] 2014 Germany & Italy & Austria the PRIPS cohorts & Bruneck cohort 59 (50–93) years 51.9/48.1 (%) 12 359 8 888 the Unified Parkinson’s Disease Rating Scale (UPDRS-I) the “Sniffin’ Sticks” 5 years 9 Michael J. Karpa [36 ] 2010 Australia the BMES cohort >60 years 685/951 19 441 3 1195 NA SDOIT 10 years 8 Mirthe M Ponsen [37 ] 2009 The Nether-lands cohort of non-parkinsonian, non-demented first-degree relatives of PD patients NA NA 5 40 0 38 the UK Parkinson’s disease Society Brain Bank (UK-PDSBB) criteria a combination of an odour detection, discrimination and identification task 5 years 9 G. Webster Ross [13 ] 2008 US & Japan Honolulu-Asia Aging Study (HAAS) 79.7 ±4.1 (range, 71–95) years men 22 1064 13 1203 the Unified Parkinson’s Disease Rating Scale BSIT 8 years 8
M/F: male/female; Tevent: people with PD and hyposmia; Tsample: people with PD; Cevent: people with PD but without hyposmia: Csample: people without PD or hyposmia; NOS: the Newcastle–Ottawa Scale; NA: not clear; UPSIT: the US version of the University of Pennsylvania Smell Identification Test; ICD-9-CM: International Classification of Diseases, 9th Revision, Clinical Modification; BSIT: the 12-Item Brief Smell Identification Test; SDOIT: the San Diego Odor Identification Test.
