Table 2: Functional enrichment analysis of downregulated genes in the old mouse ovarian secondary follicles compared to young mouse.

CategoryTermCount%P value

GOTERM_BP_DIRECTGO:0006355~regulation of transcription, DNA-templated4221.37.02E-05
GOTERM_BP_DIRECTGO:0016311~dephosphorylation84.19.84E-05
GOTERM_BP_DIRECTGO:0006351~transcription, DNA-templated3517.83.19E-04
GOTERM_BP_DIRECTGO:0045893~positive regulation of transcription, DNA-templated168.15.56E-04
GOTERM_BP_DIRECTGO:0030335~positive regulation of cell migration94.68.87E-04
GOTERM_BP_DIRECTGO:0006470~protein dephosphorylation73.62.39E-03
GOTERM_BP_DIRECTGO:0043154~negative regulation of cysteine-type endopeptidase activity involved in apoptotic process52.54.21E-03
GOTERM_BP_DIRECTGO:0030177~positive regulation of Wnt signaling pathway42.05.61E-03
GOTERM_BP_DIRECTGO:0043065~positive regulation of apoptotic process105.15.85E-03
GOTERM_BP_DIRECTGO:0097194~execution phase of apoptosis31.56.92E-03
GOTERM_CC_DIRECTGO:0005634~nucleus10653.83.23E-13
GOTERM_CC_DIRECTGO:0005737~cytoplasm10050.84.49E-08
GOTERM_CC_DIRECTGO:0005654~nucleoplasm4422.39.26E-08
GOTERM_CC_DIRECTGO:0070062~extracellular exosome5025.43.19E-06
GOTERM_CC_DIRECTGO:0043234~protein complex199.63.26E-05
GOTERM_CC_DIRECTGO:0071013~catalytic step 2 spliceosome63.02.24E-03
GOTERM_CC_DIRECTGO:0005925~focal adhesion115.64.30E-03
GOTERM_CC_DIRECTGO:0005829~cytosol2914.75.76E-03
GOTERM_CC_DIRECTGO:0030529~intracellular ribonucleoprotein complex94.61.17E-02
GOTERM_CC_DIRECTGO:0005911~cell-cell junction73.61.26E-02
GOTERM_MF_DIRECTGO:0005515~protein binding7739.16.99E-09
GOTERM_MF_DIRECTGO:0044822~poly(A) RNA binding3015.22.52E-06
GOTERM_MF_DIRECTGO:0003723~RNA binding2010.23.71E-04
GOTERM_MF_DIRECTGO:0003677~DNA binding3517.84.23E-04
GOTERM_MF_DIRECTGO:0004725~protein tyrosine phosphatase activity73.64.62E-04
GOTERM_MF_DIRECTGO:0046982~protein heterodimerization activity157.67.77E-04
GOTERM_MF_DIRECTGO:0000166~nucleotide binding3517.89.78E-04
GOTERM_MF_DIRECTGO:0016791~phosphatase activity73.61.29E-03
GOTERM_MF_DIRECTGO:0019903~protein phosphatase binding63.02.02E-03
GOTERM_MF_DIRECTGO:0005524~ATP binding2814.22.62E-03

of enriched genes in each term. The top ten terms based on P value were chosen in each category.