Table 3: Pathway enrichment analysis of differentially expressed genes in old mouse ovarian secondary follicles compared to young mouse.

CategoryTermCount%P value

Up-regulated
KEGG_PATHWAYmmu05164:Influenza A158.62.25E-11
KEGG_PATHWAYmmu05168:Herpes simplex infection158.63.13E-10
KEGG_PATHWAYmmu05162:Measles116.36.23E-08
KEGG_PATHWAYmmu05160:Hepatitis C116.36.23E-08
KEGG_PATHWAYmmu04380:Osteoclast differentiation84.64.40E-05
KEGG_PATHWAYmmu05161:Hepatitis B84.61.12E-04
KEGG_PATHWAYmmu04622:RIG-I-like receptor signaling pathway63.41.58E-04
KEGG_PATHWAYmmu04668:TNF signaling pathway74.01.69E-04
KEGG_PATHWAYmmu04620:Toll-like receptor signaling pathway63.49.93E-04
KEGG_PATHWAYmmu05133:Pertussis52.92.38E-03
Down-regulated
KEGG_PATHWAYmmu04151:PI3K-Akt signaling pathway147.14.14E-04
KEGG_PATHWAYmmu05200:Pathways in cancer147.11.31E-03
KEGG_PATHWAYmmu04550:Signaling pathways regulating pluripotency of stem cells84.11.69E-03
KEGG_PATHWAYmmu04520:Adherens junction63.02.03E-03
KEGG_PATHWAYmmu04015:Rap1 signaling pathway94.65.33E-03
KEGG_PATHWAYmmu04390:Hippo signaling pathway73.61.16E-02
KEGG_PATHWAYmmu05145:Toxoplasmosis63.01.36E-02
KEGG_PATHWAYmmu04510:Focal adhesion84.11.51E-02
KEGG_PATHWAYmmu04022:cGMP-PKG signaling pathway73.62.04E-02
KEGG_PATHWAYmmu03040:Spliceosome63.02.57E-02

Number of enriched genes in each term. The top ten terms based on P value were chosen in each category.