Effects of Proanthocyanidins on Arsenic Methylation Metabolism and Efflux in Human Hepatocytes L-02

Figure 5

Effects of proanthocyanidins (PC) on the levels of glutathione (GSH, μmol/g), arsenic (+3 oxidation state) methyltransferase (AS3MT, ng/mg) and S-adenosyl methionine (SAM, ng/mg) in L-02 cells exposed by arsenic trioxide (ATO). The GSH (a), AS3MT (b), and SAM (c) are shown. Values are means (n=3 for each group), with standard deviations represented by vertical bars. Indicating significant difference from the blank control group with 24h at P<0.05. Indicating significant difference from ATO exposure group with 24h at P<0.05. Indicating significant difference from the blank control group with 48h at P<0.05. Indicating significant difference from ATO exposure group with 48h at P<0.05.

(a)

(b)

(c)