Effects of Proanthocyanidins on Arsenic Methylation Metabolism and Efflux in Human Hepatocytes L-02

Table 2

Effects of proanthocyanidins (PC) on the changes of the difference of extracellular and intracellular concentrations of methyl arsenic (n=3).

Group	△MMA (μg/L)		△DMA (μg/L)
	24h	48h	24h	48h
ATO (25μmol/L)	25.62±2.08	28.46±3.76	11.63±1.47	20.18±1.40
ATO + PC (25μmol/L + 10mg/L)	29.35±1.52	31.87±2.36	27.13±2.01	59.74±3.40
ATO + PC (25μmol/L + 25mg/L)	29.11±1.53	36.34±2.02	33.12±2.41	73.07±2.48
ATO + PC (25μmol/L + 50mg/L)	32.51±1.72	39.06±2.87	40.01±1.85	87.23±2.47

Note: the results were described as mean ± SD. Indicating significant difference from ATO exposure group at P<0.05; ^#indicating significant difference from PC (10mg/L)-treated group at P<0.05; ^△indicating significant difference from PC (25mg/L)-treated group at P<0.05. △MMA, the difference of extracellular and intracellular concentrations of monomethylated arsenic; △DMA, the difference of extracellular and intracellular concentrations of dimethylated arsenic; ATO, arsenic trioxide.