Antimicrobial Activity of 4-Chlorocinnamic Acid Derivatives

Table 2

MFC values (μmol/mL) and MFC/MIC ratio for compounds 1-12.

Compounds	Candida albicans		Candida glabrata		Candida krusei		Candida guilliermondi
	(ATCC 90028)		(ATCC 90030)		(ATCC 34135)		(ATCC 22017)
	MFC	MFC/MIC	MFC	MFC/MIC	MFC	MFC/MIC	MFC	MFC/MIC
1	10.18	2	5.09	1	+		1.27	1
2	4.75	1	4.75	1	4.75	1	1.19	1
3	+		+		+		2.22	1
4	+		+		+		2.22	1
5	+		4.19	1	+		2.09	1
6	2.08	1	2.08	1	4.16	1	0.13	1
7	+		3.96	1	+		+
8	3.10	1	3.10	1	3.10	1	1.55	2
9	+		+		+		0.40	1
10	+		+		+		0.41	1
11	1.58	1	1.58	1	0.78	1	0.024	1
12	2.85	1	2.85	1	2.85	1	+

(+) The compounds present no MFC.
MFC/MIC relation ≥ 4: fungistatic activity. MFC/MIC < 4: fungicidal activity [14].
MFC: minimal fungicidal concentration; MIC: minimum inhibitory concentration.