TY - JOUR A2 - Bogdanos, Dimitrios P. AU - Zhang, Qiong-Yue AU - Zhang, Qiong-Fang AU - Zhang, Da-Zhi PY - 2019 DA - 2019/05/14 TI - The Impact of Steatosis on the Outcome of Liver Transplantation: A Meta-Analysis SP - 3962785 VL - 2019 AB - Background and Aims. Liver transplantation is one of the most effective treatments for end-stage liver disease as well as for cases of acute liver failure. Facing organ donor shortage, liver transplant teams had to use marginal organs. Thus, increasing availability is a key concern of donor liver grafts including steatotic livers. However, the use of steatotic liver is still controversial. The aim of this systematic review and meta-analysis was to analyze the impact of steatosis on the outcome of liver transplantation. Methods. We searched PubMed, Cochrane Library, Embase, Web of knowledge, and so on for studies published through May 31, 2018, in which patients experienced liver transplantation using fatty liver. All studies extracted outcome indicators, and we draw conclusions by contrasting outcome indicators in different groups of steatosis. Odds ratios and 95% confidence intervals were calculated. P<0.05 was considered as statistically significant difference. Results. 19 publications were included. There was no significant difference between the group of no steatosis and mild group in primary nonfunction rate (P=0.605) or early graft dysfunction rate (P=0.44). The PNF rate was significantly higher in moderate group (P=0.003) and severe group (P <0.001) compared with that in no steatosis group. The same results were seen in early graft dysfunction rate. However, graft survival rate and patient survival rate did not differ between groups. Conclusions. Livers with mild steatosis, even with moderate or severe steatosis, could be suitable donor under strict control of transplant conditions. SN - 2314-6133 UR - https://doi.org/10.1155/2019/3962785 DO - 10.1155/2019/3962785 JF - BioMed Research International PB - Hindawi KW - ER -