Research Article

Inhibition of LOXL2 Enhances the Radiosensitivity of Castration-Resistant Prostate Cancer Cells Associated with the Reversal of the EMT Process

Figure 4

Xenograft-based evaluation of the radiosensitization effect of LOXL2 knockdown in CRPC DU145 cells in vivo. (a) The time course of growth of DU145-scramble and DU145-si-LOXL2 xenograft tumors with or without a local 6 Gy dose of IR treatment. (b) Representative photo of residual tumor of DU145-scramble and DU145-si-LOXL2 cells after a 6 Gy dose of irradiation. (c) IHC staining showed an elevated E-cadherin expression in LOXL2-knockdown xenograft tumor, which represents the reversal of the EMT process in LOXL2-knockdown cells in vivo. denotes p <0.05 by Student's t-test.
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