Cytotoxic and Antitumor Activity of Lactaptin in Combination with Autophagy Inducers and Inhibitors

Figure 6

Combination of 3MA and Rap with RL2 influence on viability of MDA-MB-231 cells and MCF-7 cells. Detection of viability was produced by MTT assay. (a)–(c) Cytotoxic effect of 3MA (0–40 mM) alone and in combination with RL2 (0.1 mg/mL) on MDA-MB-231 and MCF-7 cells. (d)–(f) Cytotoxic effect of Rap (0-10 μM) alone and in combination with RL2 (0.1 mg/mL) on MDA-MB-231 and MCF-7 cells. Combinatorial index (CI) is 0.17-0.97. CI was calculated with CompuSyn version 1.0.