A Six-Gene Signature Predicts Survival of Adenocarcinoma Type of Non-Small-Cell Lung Cancer Patients: A Comprehensive Study Based on Integrated Analysis and Weighted Gene Coexpression Network

Figure 5

Network construction of the weighted coexpressed genes and their associations with clinical traits. (a) Hierarchical clustering tree of the TCGA-LUAD samples based on the DEGs. Dendrogram tips are labeled with the TCGA-LUAD unique name and experiment identifier. In the hierarchical dendrogram, lower branches correspond to higher coexpression (height = Euclidean distance). Identical colors in the ten bands below the dendrogram depict the TCGA-LUAD clinical traits. (b) Heat map view of topological overlap of coexpressed genes in different modules. The heat map was generated from the topological overlap values between genes. The genes were grouped into modules labeled by a color code, which are given under the gene dendrogram on both sides. The topological overlap was high among genes of same module. (c) Module-trait relationships for gender, histological type, lymphatic invasion, tumor status, treatment condition, and pathologic stage. Numbers shown represent Pearson correlations between the modules and traits. values are in parentheses. Numbers on the color bar refer to the strength of the correlation in the table (red = 1, blue = −1). T, extent of the tumor; N, extent of spread to the lymph nodes; M, presence of metastasis. Figure 5 was reproduced from Sun et al. [16].

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