Research Article

Expression Profile Analysis of Selenium-Related Genes in Peripheral Blood Mononuclear Cells of Patients with Keshan Disease

Table 3

Significant enrichment of Gene Ontology categories in KD patients compared to controls.

Gene ontology categoryFunctionNESa-value

Negative_regulation_of_neuron_apoptotic_processApoptosis1.650<0.001
Regulation_of_extrinsic_apoptotic_signaling_pathwayApoptosis1.665<0.001
Apoptotic_mitochondrial_changesApoptosis1.534<0.001
Apoptotic_signaling_pathwayApoptosis1.566<0.001
Cellular_modified_amino_acid_metabolic_processMetabolism1.701<0.001
Alpha_amino_acid_metabolic_processMetabolism1.494<0.001
Epidermal_cell_differentiationGrowth and development2.084<0.001
Negative_regulation_of_epithelial_cell_proliferationGrowth and development1.992<0.001
Positive_regulation_of_dendrite_developmentGrowth and development1.629<0.001
Gland_morphogenesisGrowth and development1.615<0.001
Metal_ion_transportIon transport1.794<0.001
Cation_transportIon transport1.588<0.001
Inorganic_cation_transmembrane_transporter_activityIon transport1.527<0.001
Monovalent_inorganic_cation_transportIon transport1.519<0.001

aDenotes normalized enrichment score (NES) calculated by GSEA. Positive NES indicate gene ontology up-regulated in patients compared to controls.