Research Article
Expression Profile Analysis of Selenium-Related Genes in Peripheral Blood Mononuclear Cells of Patients with Keshan Disease
Table 3
Significant enrichment of Gene Ontology categories in KD patients compared to controls.
| Gene ontology category | Function | NESa | -value |
| Negative_regulation_of_neuron_apoptotic_process | Apoptosis | 1.650 | <0.001 | Regulation_of_extrinsic_apoptotic_signaling_pathway | Apoptosis | 1.665 | <0.001 | Apoptotic_mitochondrial_changes | Apoptosis | 1.534 | <0.001 | Apoptotic_signaling_pathway | Apoptosis | 1.566 | <0.001 | Cellular_modified_amino_acid_metabolic_process | Metabolism | 1.701 | <0.001 | Alpha_amino_acid_metabolic_process | Metabolism | 1.494 | <0.001 | Epidermal_cell_differentiation | Growth and development | 2.084 | <0.001 | Negative_regulation_of_epithelial_cell_proliferation | Growth and development | 1.992 | <0.001 | Positive_regulation_of_dendrite_development | Growth and development | 1.629 | <0.001 | Gland_morphogenesis | Growth and development | 1.615 | <0.001 | Metal_ion_transport | Ion transport | 1.794 | <0.001 | Cation_transport | Ion transport | 1.588 | <0.001 | Inorganic_cation_transmembrane_transporter_activity | Ion transport | 1.527 | <0.001 | Monovalent_inorganic_cation_transport | Ion transport | 1.519 | <0.001 |
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aDenotes normalized enrichment score (NES) calculated by GSEA. Positive NES indicate gene ontology up-regulated in patients compared to controls.
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