Research Article
Erythropoiesis and Iron Homeostasis in Non-Transfusion-Dependent Thalassemia Patients with Extramedullary Hematopoiesis
Table 1
Characteristics and clinical parameters of NTDT patients (with and without EMH) and normal controls.
| | Parameters | EMH (+) | EMH (-) | Normal | p value | | n= 26 | n= 26 | n=26 | |
| | Female N () | 15 (57.7%) | 16 (61.5%) | 15 (57.7%) | 0.95 | | Age (years) | 27.5 (19-57) | 27.5 (17-63) | 28 (18-57) | 0.77 | | age <20 | 2 (7.7%) | 3(11.5%) | 3(11.5%) | 0.82 | | 20≤ age<35 | 16 (61.5%) | 16 (61.5%) | 15 (57.7%) | | | age ≥35 | 8 (30.8%) | 7 (26.9%) | 8 (30.8%) | | | Age of onset (years) | 3 (0.5-32) | 6.0 (1-24) | NA | 0.013 | | Thalassemia type | | | | 0.85 | | HbH disease | 8 (30.8%) | 9 (34.60%) | NA | | | -thalassemia intermedia | 11 (42.3%) | 10 (38.5)%) | NA | | | Moderate hemoglobin E/-thalassemia | 7 (26.9%) | 7 (26.9%) | NA | | | Splenectomy N () | 16 (61.5%) | 13 (50.0%) | NA | 0.40 | | Cholelithiasis | 14 (53.8%) | 4 (15.4%) | NA | 0.028 | | Anemic heart disease | 5 (38.5%) | 4 (17.9%) | NA | 0.16 | | Impaired glucose tolerance | 5 (19.2%) | 4 (15.4%) | NA | 1.00 | | Elevated parathyroid hormone | 4 (15.4%) | 6 (23.1%) | NA | 0.74 | | Median number of lifetime transfusion(ml/year) | 25.93(0-2488.87) | 17.67(0-318.18) | NA | 0.35 | | Previous transfusion | | | | | | Yes | 21 (80.8%) | 14 (53.8%) | NA | 0.039 | | No | 5 (19.2%) | 12 (46.2%) | NA | |
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