Research Article
Rs4846049 Polymorphism at the 3′-UTR of MTHFR Gene: Association with Susceptibility to Childhood Acute Lymphoblastic Leukemia
Table 2
Association of rs4846049 polymorphism and the risk of precursor B-ALL.
| | | | ALL (n = 95) | Control (n = 105) | value | OR (95% CI) |
| | Overall | Allele | | | | | | G | 158 (83.2) | 165 (78.6) | — | 1.000 | | T | 32 (16.8) | 45 (21.4) | 0.256 | 0.743 (0.449–1.228) | | Codominant | | | | | | GG | 65 (68.4) | 67 (63.8) | — | 1.000 | | GT | 28 (29.5) | 31 (29.5) | 0.876 | 0.931 (0.504–1.721) | | TT | 2 (2.1) | 7 (6.7) | 0.170 | 0.295 (0.059–1.471) | | Dominant | | | | | | GG | 65 (68.4) | 67 (63.8) | — | 1.000 | | GT + TT | 30 (31.6) | 38 (36.2) | 0.551 | 0.814 (0.452–1.465) | | Recessive | | | | | | GG + GT | 93 (97.9) | 98 (93.3) | — | 1.000 | | TT | 2 (2.1) | 7 (6.7) | 0.175 | 0.301 (0.061–1.487) | | Overdominant | | | | | | GG + TT | 67 (70.5) | 74 (70.5) | — | 1.000 | | GT | 28 (29.5) | 31 (29.5) | 1.000 | 0.998 (0.543–1.833) |
| | Age ≤8 years | Allele | | | | | | G | 134 (81.7) | 135 (81.3) | — | 1.000 | | T | 30 (18.3) | 31 (18.7) | 1.000 | 0.975 (0.559–1.700) | | Codominant | | | | | | GG | 54 (65.9) | 56 (67.5) | — | 1 | | GT | 26 (31.7) | 23 (27.7) | 0.732 | 1.172 (0.597–2.301) | | TT | 2 (2.4) | 4 (4.8) | 0.680 | 0.519 (0.091–2.948) | | Dominant | | | | | | GG | 54 (65.9) | 56 (67.5) | — | 1 | | GT + TT | 28 (34.1) | 27 (32.5) | 0.870 | 1.075 (0.563–2.055) | | Recessive | | | | | | GG + GT | 80 (97.6) | 79 (95.2) | — | 1 | | TT | 2 (2.4) | 4 (4.8) | 0.682 | 0.494 (0.088–2.773) | | Overdominant | | | | | | GG + TT | 56 (68.3) | 60 (72.3) | — | 1 | | GT | 26 (31.7) | 23 (27.7) | 0.612 | 1.211 (0.620–2.364) |
| | Age >8 years | Allele | | | | | | G | 24 (92.3) | 30 (68.2) | — | 1.000 | | T | 2 (7.7) | 14 (31.8) | 0.022 | 0.179 (0.037–0.863) | | Codominant | | | | | | GG | 11 (84.6) | 11 (50.0) | — | 1.000 | | GT | 2 (15.4) | 8 (36.4) | 0.141 | 0.250 (0.043–1.454) | | TT | 0 (0.0) | 3 (13.6) | 0.230 | 1.273 (0.968–1.673) | | Dominant | | | | | | GG | 11 (84.6) | 11 (50) | — | 1.000 | | GT + TT | 2 (15.4) | 11 (50) | 0.070 | 0.182 (0.032–1.018) | | Recessive | | | | | | GG + GT | 13 (100) | 19 (86.4) | — | 1.000 | | TT | 0 (0) | 3 (13.6) | 0.279 | 1.158 (0.981–1.367) | | Overdominant | | | | | | GG + TT | 11 (84.6) | 14 (63.6) | — | 1.000 | | GT | 2 (15.4) | 8 (36.4) | 0.259 | 0.318 (0.056–1.811) |
| | Male | Allele | | | | | | G | 102 (81.0) | 88 (80.0) | — | 1.000 | | T | 24 (19.0) | 22 (20.0) | 0.871 | 0.941 (0.494–1.794) | | Codominant | | | | | | GG | 41 (65.1) | 36 (65.5) | — | 1.000 | | GT | 20 (31.7) | 16 (29.1) | 0.842 | 1.098 (0.495–2.431) | | TT | 2 (3.2) | 3 (5.4) | 0.665 | 0.585 (0.093–3.702) | | Dominant | | | | | | GG | 41 (65.1) | 36 (65.5) | — | 1.000 | | GT + TT | 22 (34.9) | 19 (34.5) | 1.000 | 1.017 (0.476–2.173) | | Recessive | | | | | | GG + GT | 61 (96.8) | 52 (94.5) | — | 1.000 | | TT | 2 (3.2) | 3 (6.5) | 0.663 | 0.568 (0.091–3.532) | | Overdominant | | | | | | GG + TT | 43 (68.3) | 39 (70.9) | — | 1.000 | | GT | 20 (31.7) | 16 (29.1) | 0.842 | 1.134 (0.516–2.492) |
| | Female | Allele | | | | | | G | 56 (87.5) | 77 (77.0) | — | 1.000 | | T | 8 (12.5) | 23 (230) | 0.106 | 0.478 (0.199–1.147) | | Codominant | | | | | | GG | 24 (75.0) | 31 (62.0) | — | 1.000 | | GT | 8 (25.0) | 15 (30.0) | 0.615 | 0.689 (0.251–1.892) | | TT | 0 (0.0) | 4 (8.0) | 0.138 | 1.129 (1.002–1.272) | | Dominant | | | | | | GG | 24 (75.0) | 31 (62.0) | — | 1.000 | | GT + TT | 8 (25.0) | 19 (38.0) | 0.241 | 0.544 (0.203–1.453) | | Recessive | | | | | | GG + GT | 32 (100) | 46 (92.0) | — | 1.000 | | TT | 0 (0.0) | 4 (8.0) | 0.152 | 1.087 (1.002–1.180) | | Overdominant | | | | | | GG + TT | 24 (75.0) | 35 (70.0) | — | 1.000 | | GT | 8 (25.0) | 15 (30.0) | 0.802 | 0.778 (0.285–2.121) |
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OR, odds ratios; CI, confidential intervals. Bold, significant results.
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