Research Article
Interleukin-6 and Interleukin-15 as Possible Biomarkers of the Risk of Autoimmune Diabetes Development
Table 1
Clinical and biochemical characteristics of the group studied.
| | Autoimmune diabetes (AD) | First-degree relatives (FDR) | Control group (CG) | Value AD vs CG | Value AD vs FDR | Value FDR vs CG |
| | N | 54 | 70 | 60 | | | | | Age (years) | 34.5 (18–55) | 33.0 (18–60) | 38.5 (18–60) | 0.2 | 0.7 | 0.6 | | BMI (kg/m2) | 22.5 (17–36) | 21.9 (17–37.5) | 22.7 (18–36.3) | 0.7 | 0.3 | 0.7 | | GADA (U/ml) | 111.8 (20.2–1879.7) | 0.8 (0.6–218.7) | 0.7 (0.5–0.9) | <0.001 | <0.001 | 0.01 | | IAA (U/ml) | 3.6 (1.3–9.3) | 3.1 (4.4–17.2) | 0.2 (0.1–3.6) | <0.001 | 0.3 | <0.001 | | IA-2A (U/ml) | 6.5 (4.8–4000) | 0.6 (0.6–0.9) | 0.6 (0.4–0.7) | <0.001 | <0.001 | 0.3 | | eGDR (mg/kg/min) | 6.5 (−0.7–11.7) | 11.4 (7.0–13.9) | 12.4 (6.7–13.4) | <0.001 | <0.001 | 0.004 | | HOMAIR | 2.4 (0.3–17.5) | 1.04 (0.3–2.9) | 0.7 (0.5–1.9) | <0.001 | <0.001 | 0.02 | | IL-15 (pg/ml) | 1.7 (0.2–7.0) | 0.4 (0.2–9.1) | 0.2 (0.2–3.6) | <0.001 | 0.02 | 0.02 | | IL-6 (pg/ml) | 1.0 (0.3–9.4) | 0.7 (0.2–3.3) | 0.1 (0.01–4.7) | <0.001 | 0.01 | 0.6 |
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Data are shown as medians (interquartile range).
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