Research Article

Association between Herpes Zoster and Osteoporosis: A Nested Case-Control Study Using a National Sample Cohort

Table 1

General characteristics of the participants.

CharacteristicsAll participants
OsteoporosisControl groupP-value

Age (years, n, %)1.000
 50-5412,797 (18.7)12,797 (18.7)
 55-5912,491 (18.2)12,491 (18.2)
 60-6412,531 (18.3)12,531 (18.3)
 65-6911,070 (16.2)11,070 (16.2)
 70-748,496 (12.4)8,496 (12.4)
 75-795,845 (8.5)5,845 (8.5)
 80-843,290 (4.8)3,290 (4.8)
 85+1,972 (2.9)1,972 (2.9)
Sex (n, %)1.000
 Male9,740 (14.2)9,740 (14.2)
 Female58,752 (85.8)58,752 (85.8)
Income (n, %)1.000
 1 (lowest)13,565 (19.8)13,565 (19.8)
 29,175 (13.4)9,175 (13.4)
 310,730 (15.7)10,730 (15.7)
 414,309 (20.9)14,309 (20.9)
 5 (highest)20,713 (30.2)20,713 (30.2)
Region of residence (n, %)1.000
 Urban30,087 (43.9)30,087 (43.9)
 Rural38,405 (56.1)38,405 (56.1)
CCI (score, n, %)<0.001
 015,450 (22.6)24,544 (35.8)
 13,500 (5.1)4,397 (6.4)
 26,880 (10.0)6,951 (10.2)
 38,986 (13.1)8,021 (11.7)
 49,294 (13.6)7,449 (10.9)
 57,969 (11.6)5,876 (8.6)
 ≥ 616,413 (24.0)11,254 (16.4)
Total days of steroids used (mean, SD)107.8 (330.9)57.9 (176.3)<0.001†
Herpes zoster (n, %)3,487 (5.1)2,738 (4.0)<0.001

Abbreviations: CCI, Charlson Comorbidity Index
Chi-square test. Significance at P < 0.05
†Paired t-test. Significance at P < 0.05