N-Acetylcysteine Attenuates Cisplatin-Induced Acute Kidney Injury by Inhibiting the C5a Receptor

Figure 2

Effects of N-acetylcysteine (NAC) protect mice against Cisplatin-induced AKI. (a) Experimental protocol: C57BL/6 mice received Cisplatin (22mg/kg) by intraperitoneal injection. Animals were allocated to four groups: Control; Cisplatin; Cisplatin+NAC; NAC; (b) Serum creatinine (Cr) and (c) urea nitrogen (BUN) levels of four groups. (d) PAS staining was conducted on kidney sections in each group. (e) Semiquantitative analysis of PAS staining for the severity of renal injury. (f) Real-time PCR was used to measure renal expression of KIM-1. The values are presented as the means±SEM, n = 8. P < 0.05, P < 0.001.

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