LC-MS/MS Analysis and Hepatoprotective Activity of Artichoke (Cynara scolymus L.) Leaves Extract against High Fat Diet-Induced Obesity in Rats

Table 3

Effect of treatment with C. scolymus leaves extract on body weight.

Groups	Cont	HFD	HFD+EEA (200mg/kg/bw)	HFD+EEA (400mg/kg/bw)	HFD+ATOR
Day 0	210.00 ± 0.67	265.66 ± 3.45	260.45 ± 2.21	266.00 ± 2.13	255.78 ± 2.30
Day 65	214.50±10.40	280.10±13.93	222.5 ± 15.00^###	234.33 ±10.11^###¥	216.66 ±18.00^###

HFD groups were orally administered with ethanol extract (EEA) from leaves of C. scolymus and atorvastatin (ATOR) at the doses mentioned earlier for 60 days. Values are given as means ± SD (n = 6). p ≤ 0.01 and p ≤ 0.001 were considered significant compared to control groups; ^### p ≤ 0.001 was considered significant compared to HFD groups; ^¥p ≤ 0.05 was considered significant compared to HFD groups treated with ATOR.