LC-MS/MS Analysis and Hepatoprotective Activity of Artichoke (Cynara scolymus L.) Leaves Extract against High Fat Diet-Induced Obesity in Rats

Table 5

Effect of treatment with C. scolymus leaves extract on liver dysfunction enzymes.

Groups	AST (UI/L)	ALT (UI/L)	LDH (UI/L)	ALP (UI/L)	OCT (mg / g protein)
Cont	131.9 ± 1.50	42.76 ± 1.78	76.2 ± 2.5	64.78 ± 2.50	10.5±1.3
HFD	273.7 ±2.33	76.03±7.31	137±8.03	206.66± 6.52	7.9±0.5
HFD+EEA(200mg/kg/bw)	128.56 ±7.87^###	41.51 ± 8.03^###	70.18 ±8.03^##	72.83 ± 8.00^##	5.7±0.2^#
HFD+EEA(400mg/kg/bw)	112.18 ±5.47^###	36.56 ±1.85^###¥	63.2 ±1.85^###	72.20 ± 3.00^##	6.0±0.1
HFD+ATOR	169.18 ±4.37^###	49.36±3.73^###¥¥	84.5 ± 1.22^##	89.2 ± 4.18^##	6.4±0.7

HFD groups were orally given ethanol extract (EEA) from leaves of C. scolymus and atorvastatin (ATOR) at the doses mentioned earlier for 60 days. Values are given as means ± SD (n = 6). p ≤ 0.05 and p ≤ 0.001 were considered significant compared to control groups; ^# p ≤ 0.05, ^## p ≤ 0.01, and ^### p ≤ 0.001 were considered significant compared to HFD groups; ^¥p ≤ 0.05 and ^¥¥ p ≤ 0.01 were considered significant compared to HFD groups treated with ATOR.