LC-MS/MS Analysis and Hepatoprotective Activity of Artichoke (Cynara scolymus L.) Leaves Extract against High Fat Diet-Induced Obesity in Rats

Table 7

Effect of treatment with C. scolymus leaves extract on liver oxidative stress parameters.

Groups	Liver ROS (fluorescence intensity, FI)	TBARS (nmol MDA/ mg protein)	AOPP (nmol/mg protein)	SOD (U SOD/mg protein)	GSH (ug/mg protein)	GPx (nmol GSH min/mg protein)
Cont	70.02 ±11.23	8.64 ± 0.43	4.62 ± 0.01	3.79±0.31	5.45 ± 0.41	6.46 ± 0.60
HFD	150.30±20.34	18.15±0.92	8.85±0.08	1.91±0.04	2.06 ± 0.14	4.55 ± 0.28
HFD+EEA(200mg/kg/bw)	80.23±15.17^##	10.51± 0.56^###	5.12 ± 0.05^###	2.84±0.19^###	4.17± 0.28^###¥¥¥	5.81 ± 0.17^###
HFD+EEA(400mg/kg/bw)	84.17± 16.57^###	9.25 ± 0.61^###	4.53± 0.04^###	2.91±0.04^###	5.10 ± 0.15^###	6.00 ± 0.56^###¥
HFD+ATOR	72.49±13.45^###	10.44 ±1.03^###	4.37 ± 0.05^###	2.49±0.49^###	4.09 ± 0.33^###	5.45 ± 0.15^###

HFD groups were orally administered with ethanol extract (EEA) from leaves of C. scolymus and atorvastatin (ATOR) at the doses mentioned earlier for 60 days. Values are given as means ± SD (n = 6). p ≤ 0.001 was considered significant compared to control groups; ^### p ≤ 0.001 was considered significant compared to HFD groups; ^¥ p ≤ 0.05 and ^¥¥¥ p ≤ 0.001 were considered significant compared to HFD groups treated with
ATOR.