Research Article

Serum Tumour Markers in Testicular Germ Cell Tumours: Frequencies of Elevated Levels and Extents of Marker Elevation Are Significantly Associated with Clinical Parameters and with Response to Treatment

Table 5

Extent of marker elevations (x-fold of ULN) in relation to tumour size in CS1 patients.

bHCG [x-fold of ULN]AFP [x-fold of ULN]LDH [x-fold of ULN]
Tumour size categories (cm)n (%)MinMedian (Q1 - Q3)MaxMinMedian (Q1 - Q3)MaxMinMedian (Q1 - Q3)Max

Nonseminoma
 <=18 (10.0%)0.340.52 (0.41 - 5.25)31.690.220.43 (0.23 - 1.02)1.790.640.77 (0.70 - 0.87)1.22
 >1-229 (36.3%)0.030.45 (0.41 - 2.34)49.660.140.62 (0.25 - 2.16)22.480.550.76 (0.67 - 0.89)1.44
 >2-426 (32.5%)0.031.97 (0.45 - 4.89)560.260.105.58 (1.53 - 17.13)93.720.590.81 (0.74 - 0.96)1.25
 >4-611 (13.8%)0.170.56 (0.31 - 10.37)64.541.1411.79 (2.34 - 28.86)68.140.680.96 (0.78 - 1.00)1.46
 >65 (6.3%)0.862.21 (1.02 - 16.31)83.9038.39194.00 (144.88 - 277.50)1630.460.571.11 (1.06 - 1.18)2.71
 p-0.0673<.00010.0742
All GCT
 <=133 (11.7%)0.030.45 (0.41 - 0.46)31.690.080.34 (0.22 - 0.52)2.120.550.80 (0.71 - 1.00)2.81
 >1-291 (32.4%)0.030.45 (0.41 - 0.45)49.660.050.31 (0.22 - 0.59)22.480.510.79 (0.68 - 0.89)1.62
 >2-487 (31.0%)0.030.45 (0.41 - 2.08)560.260.080.36 (0.23 - 1.07)93.720.380.81 (0.74 - 0.92)1.28
 >4-646 (16.4%)0.030.70 (0.41 - 1.58)64.540.110.42 (0.22 - 1.14)68.140.670.90 (0.77 - 1.05)1.81
 >623 (8.2%)0.192.07 (1.02 - 6.99)83.900.170.34 (0.24 - 0.49)1630.460.011.11 (0.94 - 1.50)5.41
 p-<.00010.4388<.0001

Mann-Whitney U Test for comparisons of subgroups.