Serum Tumour Markers in Testicular Germ Cell Tumours: Frequencies of Elevated Levels and Extents of Marker Elevation Are Significantly Associated with Clinical Parameters and with Response to Treatment
Table 7
Frequencies of elevated marker levels in CS1 patients in relation to treatment.
Seminoma
Nonseminoma
bHCG elevated
LDH elevated
bHCG elevated
AFP elevated
LDH elevated
n
n (%)
n (%)
n
n (%)
n (%)
n (%)
95% CI [%]
95% CI [%]
95% CI [%]
95% CI [%]
95% CI [%]
Before orchiectomy
201
49 (24.4%)
46 (22.9%)
80
37 (46.3%)
50 (62.5%)
18 (22.5%)
18.7 - 31.0
17.4 - 29.4
35.2 - 57.7
50.9 - 72.9
14.2 - 33.5
postoperatively
201
15 (7.5%)
33 (16.4%)
80
15 (18.8%)
39 (48.8%)
6 (7.5%)
4.4 - 12.2
11.7 - 22.4
11.2 - 29.4
37.5 - 60.1
3.1 - 16.2
p-
<.0001
0.0280
<.0001
0.0009
0.0027
At completion of adjuvant therapy
201
2 (1.0%)
22 (10.9%)
80
1 (1.3%)
1 (1.3%)
10 (12.5%)
0.2 - 3.9
7.1 - 16.3
0.1 - 7.7
0.1 - 7.7
6.5 - 22.2
p-
<.0001
0.0004
<.0001
<.0001
0.0736
aMcNemar Test for comparisons of expression rates with rate before orchiectomy.
