Research Article

Identification of Upregulated HNRNPs Associated with Poor Prognosis in Pancreatic Cancer

Table 1

Cox regression multivariate analysis in TCGA-PAAD.

GroupNumHazard ration (95%CI)P value

Univariate cox model

Sex
 Female801
 Male980.809(0.537-1.219)0.312
Age(year)
 <65811
 ≥65971.396(0.918-2.121)0.118
TNM stage
 I/IIA491
 IIB/III/IV1272.050(1.217-3.452)0.007
Tumor invasion
 T1/2311
 T3/41452.022(1.072-3.815)0.030
Histologic grade
 G1311
 G2951.956(1.006-3.803)0.048
 G3482.622(1.303-5.279)0.007
 G421.650(0.211-12.885)0.633
Lymph nodes metastasis
 N0501
 N11232.154(1.282-3.618)0.004
HNRNPL expression
 Low expression891
 High expression891.861(1.222-2.833)0.004

Multivariate cox model

TNM stage
 I/IIA491
 IIB/III/IV1271.772(1.015-3.093)0.044
Histologic grade
 G1311
 G2951.667(0.856-3.246)0.133
 G3482.082(1.033-4.197)0.040
 G421.300(0.166-10.203)0.802
HNRNPL expression
 Low expression891
 High expression891.171(1.102-2.665)0.017

P < 0.05, P < 0.01.