p38/TF/HIF-α Signaling Pathway Participates in the Progression of CIPN in Mice

Figure 2

L-OHP treatment promoted macrophage HSP70 release and p38 activation in vivo and in vitro. (a) HSP70 expression in blood plasma after a single injection of vehicle or L-OHP (4 mg/kg, i.p.) at 2, 4 and 8 h (n = 4). (b) HSP70 expression in the culture medium of RAW264.7 cells after vehicle or L-OHP 10 μM) administration (n = 4). (c) p-p38 and p38 expression in the blood plasma after a single injection of vehicle or L-OHP (4 mg/kg, i.p.) at 2, 4 and 8 h (n = 4). (d) p-p38 and p38 expression in the culture medium of RAW264.7 cells after vehicle or L-OHP (10 μM) administration (n = 4). Significant difference was revealed following one-way ANOVA (∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 vs. control; Bonferroni post hoc tests).

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