p38/TF/HIF-α Signaling Pathway Participates in the Progression of CIPN in Mice

Figure 3

L-OHP induce the expression of HIF-1α and activation of MMP-9/2 in sciatic nerve. (a) HIF-1α expression in sciatic nerve after a single injection of vehicle or L-OHP (4 mg/kg, i.p.) at 2, 4 and 8 h (n = 4). (b) HIF-1α expression in the sciatic nerve after two times injection of vehicle or L-OHP (4 mg/kg, i.p., injected on 1 and 4 day) (n = 4). (c) MMP-9/2 activity in sciatic nerve after a single injection of vehicle or L-OHP (4 mg/kg, i.p.) at 2, 4 and 8 h (n = 4). (d) MMP-9/2 activity in the sciatic nerve after two times injection of vehicle or L-OHP (4 mg/kg, i.p., injected on 1 and 4 day) (n = 4). Significant difference was revealed following one-way ANOVA (∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 vs. control; Bonferroni post hoc tests).

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