Consequence of Two Protocols of Social Defeat Stress on Nicotine-Induced Psychomotor Effects in Mice

Figure 4

(a) Locomotor activity in response to saline and nicotine (0.1 mg/kg, s.c.) challenges, in mice previously exposed to repeated episodic defeat stress protocol. Short-term challenges were carried out within 3 h (saline) and 24 h (nicotine) of the final defeat, while long-term challenges were carried out after 9 and 10 days after defeat. (b) and (c) show the time course of nicotine-induced locomotor effects in 5-min bins, during short-term (b) and long-term (c) challenges. +Difference between saline and nicotine challenges (within-group comparison). #Difference between respective short- and long-term challenges. In all cases, p<0.05.

(a)

(b)

(c)