Prognostic Nomogram for the Overall Survival of Patients with Newly Diagnosed Multiple Myeloma

Table 1

Clinical and laboratory characteristics of patients with newly diagnosed multiple myeloma.

Characteristics	Training cohort		Validation cohort
	(n = 214)		(n = 90)
	Number	%	Number	%
Age at diagnosis, years
Median ± SD	60.2 ± 10.6		60.9 ± 11.1
Range	34−89		34−84
Sex
Male	121	56.5	51	56.7
Female	93	43.5	39	43.3
Clonal BM plasma cells, %
Median	36.4 ± 24.8		38.2 ± 26.8
Range	0.5−97.0		0.5−97.0
Hemoglobin
≥100 g/L	91	42.5	41	45.6
<100 g/L	123	57.5	49	54.4
Serum albumin
≥35 g/L	73	34.1	29	32.2
<35 g/L	141	65.9	61	67.8
Serum LDH
<250 U/L	178	83.2	74	82.2
≥250 U/L	36	16.8	16	17.8
Serum creatinine
<177 μmol/L	172	80.4	72	80.0
≥177 μmol/L	42	19.6	18	20.0
Serum calcium
<2.75 mmol/L	200	93.5	83	92.2
≥2.75 mmol/L	14	6.5	7	7.8
Serum β2-microglobulin
<5.5 mg/L	120	56.1	48	53.3
≥5.5 mg/L	94	43.9	42	46.7
1q21 gain
Negative	119	55.6	54	60.0
Positive	95	44.4	36	40.0
del (17p)
Negative	186	86.9	80	88.9
Positive	28	13.1	10	11.1
t (4;14)
Negative	189	88.3	83	92.2
Positive	25	11.7	7	7.8
t (11;14)
Negative	169	79.0	69	76.7
Positive	45	21	21	23.3
t (14;16)
Negative	206	96.3	85	94.4
Positive	8	3.7	5	5.6

Abbreviations: SD, standard deviation; BM, bone marrow; LDH, lactate dehydrogenase.