BioMed Research International / 2019 / Article / Tab 1

Research Article

Effect and Mechanism of Survivin on Hypoxia-Induced Multidrug Resistance of Human Laryngeal Carcinoma Cells

Table 1

Effect of survivin expression inhibition on chemosensitivity in hypoxic Hep-2 cells.

DrugIC50 (μg/ml)
Untreated controlNegative controlSurvivin-siRNA

Paclitaxel39.05×10-3±0.2239.43×10-3±0.1811.42×10-3±0.39
5-Fu244.23±0.32242.63±0.5893.38±0.53
Doxorubicin3.93±0.133.88±0.152.85±0.37
Gemcitabine37.90±0.2838.49±0.1829.58±0.43
Cisplatin8.95±0.159.14±0.145.82±0.30

IC50 is the concentration of each drug that caused a 50% reduction in the number of cells.
Mean ± SD of three individual experiments are shown. : vs. Untreated control and Negative control.

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