Effect and Mechanism of Survivin on Hypoxia-Induced Multidrug Resistance of Human Laryngeal Carcinoma Cells

Table 1

Effect of survivin expression inhibition on chemosensitivity in hypoxic Hep-2 cells.

Drug	IC50 (μg/ml)
	Untreated control	Negative control	Survivin-siRNA
Paclitaxel	39.05×10-3±0.22	39.43×10-3±0.18	11.42×10-3±0.39
5-Fu	244.23±0.32	242.63±0.58	93.38±0.53
Doxorubicin	3.93±0.13	3.88±0.15	2.85±0.37
Gemcitabine	37.90±0.28	38.49±0.18	29.58±0.43
Cisplatin	8.95±0.15	9.14±0.14	5.82±0.30

IC₅₀ is the concentration of each drug that caused a 50% reduction in the number of cells.
Mean ± SD of three individual experiments are shown. : vs. Untreated control and Negative control.