Effect and Mechanism of Survivin on Hypoxia-Induced Multidrug Resistance of Human Laryngeal Carcinoma Cells

Table 2

Effect of survivin expression inhibition on chemosensitivity in hypoxic AMC-HN-8 cells

Drug	IC50 (μg/ml)
	Untreated control	Negative control	Survivin-siRNA
Paclitaxel	37.22×10-3±0.14	37.31×10-3±0.15	10.62×10-3±0.32
5-Fu	234.28±0.27	227.12±0.18	92.22±0.41
Doxorubicin	3.84±0.83	3.80±0.28	2.67±0.14
Gemcitabine	36.77±0.12	37.24±0.19	27.62±0.18
Cisplatin	8.22±0.36	8.52±0.42	5.72±0.14

IC₅₀ is the concentration of each drug that caused a 50% reduction in the number of cells.
Mean ± SD of three individual experiments are shown. : vs. Untreated control and Negative control.