BioMed Research International / 2019 / Article / Tab 2

Research Article

Effect and Mechanism of Survivin on Hypoxia-Induced Multidrug Resistance of Human Laryngeal Carcinoma Cells

Table 2

Effect of survivin expression inhibition on chemosensitivity in hypoxic AMC-HN-8 cells

DrugIC50 (μg/ml)
Untreated controlNegative controlSurvivin-siRNA

Paclitaxel37.22×10-3±0.1437.31×10-3±0.1510.62×10-3±0.32
5-Fu234.28±0.27227.12±0.1892.22±0.41
Doxorubicin3.84±0.833.80±0.282.67±0.14
Gemcitabine36.77±0.1237.24±0.1927.62±0.18
Cisplatin8.22±0.368.52±0.425.72±0.14

IC50 is the concentration of each drug that caused a 50% reduction in the number of cells.
Mean ± SD of three individual experiments are shown. : vs. Untreated control and Negative control.

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