A Human Umbilical Cord Mesenchymal Stem Cell-Conditioned Medium/Chitosan/Collagen/β-Glycerophosphate Thermosensitive Hydrogel Promotes Burn Injury Healing in Mice

Figure 4

MSC-CM/hydrogel application promotes the formation of granulation tissue in a mouse model of third-degree burns. (a) H&E stained images of wounded skin in the four groups on day 14: UM (unconditioned medium) group (I, II), MSC-CM group (III, IV), UM/hydrogel group (V, VI), and MSC-CM/hydrogel group (VII, VIII). Bars in I, III, V, and VII represent 200 μm and those in II, IV, VI, and VIII represent 50 μm. Statistical analyses of the granulation tissue thickness (b), fibroblast density (c), and capillaries (d) on day 14 of wound healing. The asterisk () indicates between the compared groups.

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