The Association between PON1 (Q192R and L55M) Gene Polymorphisms and Risk of Cancer: A Meta-Analysis Based on 43 Studies

Table 1

Characteristics of qualified case-control studies included in the meta-analysis of PON1-Q192R.

Author	Year	Ethnicity	Genotyping Method	Control of source	Cancer Type	Case			Control			HWE
						QQ	QR	RR	QQ	QR	RR		p	p(HWE)
Stevens et al.	2006	Caucasian	PCR-RFLP	P-B	Breast Cancer	259	182	42	238	198	47	0.38	0.54	Y
Gallicchio et al.	2007	Caucasian	PCR-RFLP	P-B	Breast Cancer	38	15	5	469	353	82	1.93	0.19	Y
Antognelli et al.	2009	Caucasian	PCR-RFLP	P-B	Breast Cancer	484	50	13	340	152	52	27.19	0.00	N
Hussein et al.	2011	Caucasian	PCR-RFLP	P-B	Breast Cancer	51	41	8	46	42	12	0.25	0.62	Y
Naidu et al.	2010	Asian	PCR-RFLP	H-B	Breast Cancer	200	158	29	115	115	22	0.81	0.37	Y
Tang et al.	2017	Asian	TaqMan	P-B	Esophagogastric	408	501	132	691	776	207	0.23	0.63	Y
Uluocak et al.	2017	Caucasian	PCR-RFLP	H-B	Prostate Cancer	24	17	8	45	42	11	0.06	0.80	Y
Wu et al.	2017	Asian	TaqMan	H-B	Breast Cancer	155	156	54	167	156	55	3.42	0.06	Y
Kaya et al.	2016	Caucasian	TaqMan	H-B	Breast Cancer	10	11	11	5	13	17	0.88	0.35	Y
Tomatir et al.	2015	Caucasian	PCR-RFLP	H-B	Hematologic Cancer	36	20	4	58	24	2	0.07	0.79	Y
Tomatir et al.	2015	Caucasian	PCR-RFLP	H-B	Hematologic Cancer	33	21	6	58	24	2	0.07	0.08	Y
Attar et al.	2015	Caucasian	PCR-RFLP	H-B	Uterine Leiomyoma	60	8	8	50	47	6	1.39	0.24	Y
Eom et al.	2015	Asian	PCR-RFLP	H-B	Lung Cancer	37	170	209	48	188	180	0.01	0.92	Y
Ahmed et al.	2015	Asian	PCR-RFLP	P-B	Colorectal Cancer	30	16	4	20	36	24	0.76	0.38	Y
Akkız et al.	2013	Caucasian	PCR-RFLP	P-B	Hepatocellular Carcinoma	109	95	13	115	88	14	0.27	0.60	Y
Vasconcelos et al.	2014	Mixed	TaqMan	H-B	Embryonal Tumors	36	85	41	104	160	72	0.51	0.48	Y
Conesa-Zamora et al.	2013	Caucasian	TaqMan	H-B	Lymphomas	83	99	33	100	104	10	7.00	0.01	N
Zhao et al.	2012	Asian	TaqMan	H-B	Glioma	161	158	52	159	167	52	0.59	0.44	Y
De Aguiar Goncalves et al.	2012	Mixed	TaqMan	H-B	Hematologic Tumor	96	102	40	74	106	54	1.790	0.180	Y
Kokouva et al.	2012	Caucasian	PCR-RFLP	H-B	Hematologic Cancer	213	88	15	181	141	29	0.04	0.83	Y
Aksoy-Sagirli et al.	2011	Caucasian	PCR-RFLP	H-B	Lung Cancer	93	111	19	121	93	20	0.13	0.72	Y
Uyar et al.	2011	Caucasian	PCR-RFLP	P-B	Renal Cell Cancer	38	21	1	27	27	6	0.04	0.84	Y
Lurie et al.	2008	Mixed	TaqMAN	P-B	Ovarian Cancer	66	120	86	122	211	111	1.07	0.30	Y
Ergen et al.	2010	Caucasian	PCR-RFLP	H-B	Osteosarcoma	27	21	2	15	33	2	0.06	0.80	Y
Martinez et al.	2010	Caucasian	TaqMan	H-B	Brain Tumor	31	33	9	22	89	109	0.37	0.54	Y
Ozturk et al.	2009	Caucasian	PCR-RFLP	H-B	Bladder Cancer	8	53	15	37	84	14	10.71	<0.001	N
Gold et al.	2009	Mixed	PCR-RFLP	P-B	Multiple Myeloma	10	19	13	9	27	19	0.01	0.91	Y
Arpaci et al.	2009	Caucasian	PCR-RFLP	H-B	Ovarian Cancer	38	6	6	17	29	6	1.46	0.23	Y
Rajaraman et al.	2008	Mixed	TaqMan	H-B	Brain Tumor	266	207	39	244	165	44	4.10	0.04	N
Searles Nielsen et al.	2005	Mixed	TaqMan	P-B	Brain Tumor	32	28	6	100	105	31	0.17	0.68	Y
Van der Logt et al.	2005	Caucasian	PCR-RFLP	P-B	Colorectal Cancer	180	150	24	158	120	17	0.87	0.35	Y
Lincz et al.	2004	Caucasian	PCR-RFLP	P-B	Multiple Myeloma	33	41	16	103	74	22	2.35	0.13	Y
Kerridge et al.	2002	Caucasian	PCR-RFLP	P-B	Lymphoma	73	50	39	103	74	22	2.35	0.13	Y
Antognelli et al.	2005	Caucasian	PCR-RFLP	H-B	Prostate Cancer	197	168	20	212	85	64	67.85	<0.001	N
Herrera et al.	2015	Mixed	TaqMan	H-B	Brain Tumor	15	32	20	12	32	14	0.64	0.42	Y
Kafadar et al.	2006	Caucasian	PCR-RFLP	H-B	Brain Tumor	43	26	15	24	18	8	1.96	0.16	Y
J. De Roos et al.	2006	Mixed	TaqMan	P-B	Hematologic Cancer	540	453	127	415	403	117	1.53	0.22	Y
Stevens et al.	2008	Mixed	TaqMan	P-B	Prostate Cancer	624	537	95	656	487	121	4.74	0.03	N
Antognelli et al.	2013	Caucasian	PCR-RFLP	H-B	Prostate Cancer	291	250	30	707	258	203	244.08	<0.001	N
Wang et al.	2012	Asian	PCR-RFLP	P-B	Lung Cancer	36	177	143	38	84	62	0.93	0.33	Y
Lee et al.	2005	Asian	TaqMan	P-B	Lung Cancer	24	80	73	11	89	77	4.999	0.025	N
Agachan et al.	2006	Caucasian	PCR-RFLP	P-B	Breast Cancer	17	4	12	6	29	17	1.461	0.230	Y
Hemati et al.	2019	Asian	PCR-RFLP	H-B	Gastric Cancer	39	41	10	62	26	2	0.03	0.87	Y

Abbreviations: PCR-RFlP, polymerase chain reaction-restriction fragment length polymorphism; HWE, Hardy–Weinberg equilibrium; Y, polymorphisms conforming to HWE in the control group; N, polymorphisms not conforming to HWE in the control group; H-B, hospital based; P-B, population based.