The Association between PON1 (Q192R and L55M) Gene Polymorphisms and Risk of Cancer: A Meta-Analysis Based on 43 Studies
Table 3
Results of meta-analysis for PON1-Q192R polymorphism and cancer risk.
Variables
Case/control
R vs. Q
RR vs. QQ
RQ vs. QQ
RR+RQ vs. QQ
RR vs. RQ+QQ
OR(95% CI)
I2(%)
OR(95% CI)
I2(%)
OR(95% CI)
I2(%)
OR(95% CI)
I2(%)
OR(95% CI)
I2(%)
Total
11412/13936
0.897(0.798-1.008)
0
86.8
0.855(0.683-1.073)
0
81.1
0.861(0.724-1.023)
0
86.7
0.857(0.730-1.008)
0
86.7
0.914(0.758-1.102)
0
78.1
Breast cancer
2005/2748
0.643(0.440-0.942)
0
91.4
0.542(0.331-0.886)
0
74
0.529(0.325-0.861)
0
89.1
0.534(0.330-0.865)
0
90.6
0.720(0.492-1.054)
0.010
62.3
Gastrointestinal cancer
1752/2356
1.008(0.700-1.450)
0
88.1
0.969(0.463-2.025)
0.000
80.2
1.079(0.761-1.529)
0.002
75.7
1.038(0.682-1.580)
0.000
85.0
0.968(0.547-1.711)
0.013
68.5
Prostate cancer
2261/2891
0.967(0.886-1.055)
0.748
0
0.563(0.313-1.015)
0.001
83
1.544(0.969-2.458)
0
90.9
1.249(1.030-1.514)
0.083
55
0.498(0.235-1.053)
0
90.3
Hematologic tumor
2303/2355
1.113(0.852-1.453)
0
85.5
1.358(0.787-2.341)
0
82
0.943(0.740-1.202)
0.007
62.3
1.040(0.774-1.397)
0
78.2
1.364(0.863-2.157)
0
77.8
Lung cancer
1172/1011
1.179(0.949-1.464)
0.04
63.8
1.244(0.665-2.326)
0.005
76.6
1.214(0.704-2.094)
0.004
77.5
1.262(0.741-2.149)
0.003
78.6
1.201(0.997-1.449)
0.442
0
Brain tumor
1173/1395
0.759(0.505-1.140)
0
89.2
0.576(0.266-1.248)
0
85.9
0.778(0.539-1.124)
0.006
69
0.696(0.431-1.123)
0
84.4
0.698(0.388-1.256)
0
79.4
Ovarian cancer
322/496
0.665(0.189-2.337)
0
92.7
0.940(0.314-2.813)
0.087
65.8
0.328(0.030-3.572)
0
94.6
0.443(0.060-3.283)
0
94.5
1.359(0.985-1.875)
0.658
0
Other cancers
424/684
0.809(0.481-1.362)
0
85.1
1.264(0.515-3.101)
0.022
65
0.670(0.250-1.798)
0
89.4
0.741(0.299-1.838)
0
89.1
1.352(0.797-2.294)
0.209
31.8
Ethnicities
Caucasian
4424/6292
0.815(0.658-1.011)
0
90.1
0.784(0.516-1.193)
0
84.5
0.731(0.528-1.010)
0
91.1
0.744(0.557-0.993)
0
90.3
0.893(0.608-1.311)
0
83.5
Asian
3253/3629
0.840(0.840-1.244)
0
89.9
1.019(0.689-1.506)
0
78.5
1.020(0.779-1.337)
0
76.3
1.022(0.758-1.377)
0
83.0
1.052(0.850-1.303)
0.025
54.4
Mixed
3735/4015
0.981(0.877-1.098)
0.035
51.6
0.913(0.727-1.145)
0.062
46.2
1.012(0.873-1.174)
0.109
38.8
0.990(0.851-1.153)
0.057
47
0.929(0.770-1.119)
0.115
38.1
Control source
Population based
6871/8354
0.849(0.717-1.004)
0
88.8
0.802(0.604-1.065)
0
79.1
0.793(0.638-0.984)
0
85
0.789(0.630-0.988)
0
87.9
0.920(0.749-1.130)
0
70.3
Hospital based
4309/5667
0.897(0.798-1.008)
0
85.1
0.948(0.655-1.374)
0
83.2
0.927(0.704-1.221)
0
87.3
0.923(0.726-1.175)
0
85.5
0.967(0.696-1.342)
0
83.3
Genotype method
PCR-RFLP
5445/6900
0.884(0.735-1.064)
0
88.4
0.888(0.735-1.064)
0
88.4
0.815(0.607-1.094)
0
90.4
0.839(0.646-1.091)
0
89.4
0.938(0.692-1.271)
0
80.5
TaqMan
5967/7036
0.922(0.801-1.060)
0
83
0.834(0.622-1.117)
0
81.3
0.952(0.824-1.099)
0.001
61.1
0.906(0.762-1.078)
0
76.7
0.915(0.736-1.139)
0
73.5
Notes: statistically significant (P<0.05); P : P value of Q test for heterogeneity test; I2: 0%–25% means no heterogeneity, 25%–50% means modest heterogeneity, and 50% means high heterogeneity. Abbreviations: CI, confidence interval; OR, odds ratio; PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism.
