Spica Prunellae Extract Enhances Fluorouracil Sensitivity of 5-Fluorouracil-Resistant Human Colon Carcinoma HCT-8/5-FU Cells via TOP2<i>α</i> and miR-494

<div>Identification of DEGs and hub genes. Enriched ontology clusters of (a) upregulated and (b) downregulated DEGs colored by cluster ID. (c) The PPI network of the top 15 hub genes. (d, e) Selection of the top 2 modules by using the MCODE plug-in to detect significant modules in this PPI network.</div>

BioMed Research International

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Figure 1

Figure 1: Spica Prunellae Extract Enhances Fluorouracil Sensitivity of 5-Fluorouracil-Resistant Human Colon Carcinoma HCT-8/5-FU Cells via TOP2<i>α</i> and miR-494 

Figure 1 | Spica Prunellae Extract Enhances Fluorouracil Sensitivity of 5-Fluorouracil-Resistant Human Colon Carcinoma HCT-8/5-FU Cells via TOP2α and miR-494 