Serum Amyloid A Protein as a Potential Biomarker for Severity and Acute Outcome in Traumatic Brain Injury
Figure 2
Neuronal loss and cortical lesion are injury severity dependent. Representative sections of injured brains stained with cresyl violet. Blue box represents the cortical brain region analyzed. Severe injury has an increased lesion score compared to mild injury at 1 day after CCI (a). The number of dying neurons around the cortical impact site in sham mice or after mild injury is fewer compared to severe injury (b). Increased numbers of NeuN positive cells in sham mice are reduced 2 folds after mild TBI, and 4 folds after severe injury (c). Representative images show the number of dying neurons around the cortical impact site in sham, and mild or severe injured mice indicated by TUNEL (green), NeuN (red), and DAPI positive cells (blue). Mean±sem, n=5/group, p<0.001, p<0.01, p<0.05 injured vs. sham, and #p<0.05 mild vs. severe injury.