Serum Amyloid A Protein as a Potential Biomarker for Severity and Acute Outcome in Traumatic Brain Injury

Figure 3

Microglia activation and neutrophil infiltration are dependent on injury severity. Immunofluorescence images show microglia/macrophages from sham to mild and severe injury (Iba-1, red) (a). Quantitative analysis of Iba-1 immunoreactivity is reduced in injured brains in sham mice and increased 3 folds after mild TBI and 5 folds after severe injury (b). Immunofluorescence images show infiltrated neutrophils from sham to mild and severe injury (Ly-6B.2, green; dapi, blue) (c). The number of Ly-6B.2 positive cells increased in injured brains 3 folds after mild TBI, and 5 folds after severe injury (d). Mean±sem, n=5/group, p<0.001, p<0.01 injured vs. sham, and #p<0.05, ##p<0.01 mild vs. severe injury.

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