TROAP Promotes Breast Cancer Proliferation and Metastasis
Figure 1
TROAP is upregulated in BC tissues and cell lines. (a) TROAP mRNA levels in 1085 BC tissues and 291 noncancerous tissues from the TCGA dataset. TROAP is upregulated in BC tissues (N, noncancerous; T, tumor; P<0.001). (b) TROAP mRNA levels in different molecular subtypes of BC and normal breast tissue. TROAP is upregulated in all molecular subtypes of BC (P<0.001). (c) TROAP mRNA levels are elevated in 30 pairs of BC tissues compared with matched tissues (P<0.001, n=30). (d) TROAP protein levels in 10 pairs of BC tissues and matched noncancerous tissues were detected by WB. (e) TROAP mRNA expression levels were determined by qRT-PCR in one immortalized breast cell line, MCF-10A, and three human BC cell lines, MCF-7, MDA-MB-231, and MDA-MB-468. (f) TROAP protein expression levels were determined by WB in one immortalized breast cell line, MCF-10A, and three human BC cell lines, MCF-7, MDA-MB-231, and MDA-MB-468 (P<0.001, P<0.005). The qRT-PCR and WB data are presented as the mean ± SD.