The Development and Lifetime Stability Improvement of Guanosine-Based Supramolecular Hydrogels through Optimized Structure

Figure 6

(a) B(OH)4- combined with guanosine produces a guanosine-borate (GB) ester. (b) Natural guanosine is cross-linked with Mg 2+ and benzene-1,4-diboronic acid to form functional G-quartet hydrogels. (c) Self-assembly of 2-formylphenylboronic acid (2-FPBA) and tris(2-aminoethyl)amine (TAEA) in the presence of KCl can prepare G-quartet hydrogels. (d) Photoactivated dopamine-conjugated platinum (IV) anticancer complex (Pt-DA) incorporated into G-quadruplex G4K+ borate hydrogels via borate ester linkages.

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