Analysis of the UGT1A1 Genotype in Hyperbilirubinemia Patients: Differences in Allele Frequency and Distribution
Table 1
Demographic information and biochemical parameters in Gilbert patients.
Total
-3279T>G
-3279T>G
-3279T>G
P
Heterozygote
Homozygote
Wildtype
N
55
24(43%)
23(42%)
8(15%)
Sex(M/F)
41M/14F
19M/5F
17M/6F
5M/3F
0.64
Age, y
34(3~76)
33.5(3~66)
34.0(21~61)
46.0(18~76)
0.25
ALT(U/L)
26.73±11.85
27.87±12.76
26.13±12.34
25.00±7.76
0.80
AST(U/L)
24.05±12.02
27.83±16.73
20.47±4.97
23.00±4.95
0.10
ALB(g/L)
46.7(41.3~52.1)
47.3(41.3~52.1)
46.4(44.4~51.8)
45.0(42.8~49.0)
0.18
GGT(U/L)
18.93±6.96
18.42±7.24
18.0±6.26
24.12±7.06
0.09
TBil(μmol/L)
43.9(28.8~82.9)
44.3(30.1~70.2)
42.4(28.8~82.9)
38.0(32.1~57.9)
0.39
DBil(μmol/L)
11.84±3.33
12.17±3.40
11.93±3.21
10.64±3.62
0.53
IBil(μmol/L)
30.7(21.4~70.4)
32.0(22.2~53.1)
30(21.4~70.4)
29.4(23.9~48.7)
0.32
Wild-type TT; Heterozygote TG; Homozygote GG Variables were checked by Kolmogorov-Smirnov test or Shapiro-Wilk test for normal distribution analysis. Normally distributed data are expressed as mean±SD and compared by one-way ANOVA. Not normally distributed data were presented as median and range and were compared by Kruskal-Wallis H test. Categorical variables were analyzed using Chi-square test.
