Research Article

Predicting MicroRNA Target Genes and Identifying Hub Genes in IIA Stage Colon Cancer Patients Using Bioinformatics Analysis

Table 3

GO analysis of differentially expressed genes associated with IIA stage colon cancer.

regulationCategoryTermCountP-ValueFold EnrichmentFDR

upGOTERM_BP_FATGO:0010646~regulation of cell communication23424.920132.36E-121.5267447784.63E-09
upGOTERM_BP_FATGO:0023051~regulation of signaling23625.133124.03E-121.5147158037.91E-09
upGOTERM_BP_FATGO:0007399~nervous system development18019.169338.89E-121.634444961.75E-08
upGOTERM_BP_FATGO:0010604~positive regulation of macromolecule metabolic process22023.429182.72E-111.5178260655.34E-08
upGOTERM_BP_FATGO:0007167~enzyme linked receptor protein signaling pathway9810.436632.73E-112.0241152175.37E-08
upGOTERM_MF_FATGO:0005057~receptor signaling protein activity272.8753992.69E-083.5804760194.39E-05
upGOTERM_MF_FATGO:0000982~transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding414.3663471.00E-062.330151060.001631
upGOTERM_MF_FATGO:0019899~enzyme binding13614.483491.81E-061.4819136820.002953
upGOTERM_MF_FATGO:0008092~cytoskeletal protein binding757.987223.96E-061.7281651390.006455
upGOTERM_MF_FATGO:0019904~protein domain specific binding596.283284.69E-061.8731733930.00764
upGOTERM_CC_FATGO:0030054~cell junction12313.099042.20E-091.7116734033.35E-06
upGOTERM_CC_FATGO:0031252~cell leading edge444.6858362.05E-072.3785067073.12E-04
upGOTERM_CC_FATGO:0005912~adherens junction697.3482433.11E-071.9079618094.74E-04
upGOTERM_CC_FATGO:0070161~anchoring junction697.3482437.57E-071.8623424690.001153
downGOTERM_BP_FATGO:0007399~nervous system development54618.86013.19E-361.6193876.50E-33
downGOTERM_BP_FATGO:0006357~regulation of transcription from RNA polymerase II promoter46816.16584.34E-321.641458.83E-29
downGOTERM_BP_FATGO:0051254~positive regulation of RNA metabolic process37512.953377.66E-291.7056611.56E-25
downGOTERM_BP_FATGO:0006366~transcription from RNA polymerase II promoter45315.647671.98E-281.6019344.03E-25
downGOTERM_BP_FATGO:1903508~positive regulation of nucleic acid-templated transcription36012.435232.90E-281.7175465.91E-25
downGOTERM_MF_FATGO:0000981~RNA polymerase II transcription factor activity, sequence-specific DNA binding1886.4939553.54E-171.7992496.12E-14
downGOTERM_MF_FATGO:0001067~regulatory region nucleic acid binding2257.7720217.28E-161.6633861.34E-12
downGOTERM_MF_FATGO:0000975~regulatory region DNA binding2247.7374781.35E-151.6579282.31E-12
downGOTERM_MF_FATGO:0044212~transcription regulatory region DNA binding2237.7029361.78E-151.6563313.08E-12
downGOTERM_MF_FATGO:0043565~sequence-specific DNA binding2679.2227983.59E-151.5663146.15E-12
downGOTERM_CC_FATGO:0005654~nucleoplasm63221.830742.75E-181.3317864.42E-15
downGOTERM_CC_FATGO:0043005~neuron projection2338.0483595.31E-121.5227838.54E-09
downGOTERM_CC_FATGO:0097458~neuron part29710.259078.60E-111.4066491.38E-07
downGOTERM_CC_FATGO:0098644~complex of collagen trimers180.6217629.04E-104.9408761.45E-06