Impact of a Multichannel Blocker in Attenuating Intramyocardial Artery Remodeling in Hypertensive Rats through Increased Nitric Oxide Bioavailability

Table 2

Geometry and collagen in the intramyocardial artery from WKY, SHR, and SHR-D.

Structural parameters	WKY	SHR	SHR-D
ED (μm)	151 (150-219)	349 (312-377	250 (248-303
LD (μm)	68 (60-129)	201 (110-212	176 (144-226
WW (μm)	43 (36-47)	82 (71-107	49 (38-52)^##
W/L (%)	60 (37-74)	46 (33-80)	27 (18-36
CSA (μm^2)	15058 (14381-21195)	70227 (54016-82310	31885 (25215-38623)^##
CD (%)	13.83 (11.81-21.40)	41.66 (40.68-52.78	15.38 (12.57-17.25)^##
NO (μM)	1.76 (1.68-1.84)	1.35 (1.32-1.40	1.66 (1.46-1.80)^#

ED, external diameter; LD, lumen diameter; WW, wall width; W/L, wall/lumen ratio; CSA, cross-sectional area; CD, collagen volume density; NO, nitric oxide. Data are expressed as median (25th-75th percentiles). Statistically significant differences are shown (P<0.05 versus WKY; P<0.01 versus WKY; ^#P<0.05 versus SHR; ^##P<0.01 versus SHR). Geometry and collagen (n=6) and NO (n=5).