BioMed Research International / 2019 / Article / Fig 7

Review Article

Clinical Efficacy of Extracorporeal Cardiopulmonary Resuscitation for Adults with Cardiac Arrest: Meta-Analysis with Trial Sequential Analysis

Figure 7

(a) Random-effect model of trial sequential analysis for 30-day favorable neurologic outcome in OHCA patients. Type 1 error is =5%; a diversity-adjusted information size of 9767 participants calculated on the basis of a good neurologic outcome rate of 3.1% in the CCPR group, 20% increase in outcome, α = 5% (two sided), β = 20%, and = 76%. Complete blue line represents cumulative Z-curve, which just reached the conventional boundary (dashed red line) and did not cross the trial sequential monitoring boundary (dashed gray line). (b) Random-effect model of trial sequential analysis for 30-day favorable neurologic outcome in IHCA patients. Type 1 error is =5%; a diversity-adjusted information size of 263 participants calculated on the basis of a good neurologic outcome rate of 12.5% in the CCPR group, 20% increase in outcome, α = 5% (two sided), β = 20%, and = 0%. Complete blue line represents cumulative Z-curve, which crossed conventional boundary (dashed red line) and the trial sequential monitoring boundary (dashed gray line).
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