Review Article

MSC-Derived Exosomes-Based Therapy for Peripheral Nerve Injury: A Novel Therapeutic Strategy

Table 1

The characteristics of exosomes and microvesicles.

ā€‰ExosomesMicrovesicles

Size40-150 nm100-1000 nm
Size rangenarrowbroad
Density1.18-1.21 g/ml1.16 g/ml
OriginThe invagination of plasma membrane (PM) forms endosomes;
endosomes buds inward to form intraluminal vesicles
The outward shedding of PM
Main formation mechanismsESCRT-dependent and independent mechanismCalcium-dependent mechanism
MakerCD 9, CD 63, CD 91, TSG 101, ALIXIntegrins, selectins, tissue factors
ContentmRNA, miRNA, lncRNA, DNA, protein, lipid, MHCmRNA, miRNA, protein

ESCRT: endosomal sorting complex required for transport.