Review Article
MSC-Derived Exosomes-Based Therapy for Peripheral Nerve Injury: A Novel Therapeutic Strategy
Table 1
The characteristics of exosomes and microvesicles.
| ā | Exosomes | Microvesicles |
| Size | 40-150 nm | 100-1000 nm | Size range | narrow | broad | Density | 1.18-1.21 g/ml | 1.16 g/ml | Origin | The invagination of plasma membrane (PM) forms endosomes; endosomes buds inward to form intraluminal vesicles | The outward shedding of PM | Main formation mechanisms | ESCRT-dependent and independent mechanism | Calcium-dependent mechanism | Maker | CD 9, CD 63, CD 91, TSG 101, ALIX | Integrins, selectins, tissue factors | Content | mRNA, miRNA, lncRNA, DNA, protein, lipid, MHC | mRNA, miRNA, protein |
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ESCRT: endosomal sorting complex required for transport.
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