Excess Glutamate May Cause Dilation of Retinal Blood Vessels in Glutamate/Aspartate Transporter-Deficient Mice

Figure 4

The longitudinal changes in the thickness of the retinal layers. Open circles, C57BL/6J; closed circles, GLAST^−/− mice. (a) Thickness changes in the combined retinal nerve fiber, ganglion cell and inner plexiform layers. (b) Thickness changes in the combined inner nuclear and outer plexiform layers. (c) Thickness changes in the outer nuclear layer. (d) Thickness changes in the combined inner segment and outer segment layers. (e) Thickness changes in the combined the retinal pigment epithelium and choroid. Animal numbers: GLAST^−/−, P22 (n = 6), P44∼P114 (n = 4), P156 (n = 5); C57BL/6J, P22∼P148 (n = 4). Statistical significance: ; (Student’s t-test).

(a)

(b)

(c)

(d)

(e)