Dihydromyricetin Ameliorates Cardiac Ischemia/Reperfusion Injury through Sirt3 Activation

Figure 3

DHM attenuated the mitochondrial dysfunction after MI/R. (a) The morphology of mitochondria (m). (b, c) ATP content and citrate synthase (CS) activity. (d) Mitochondrial DNA content. (e) ROS levels. (f) Manganese superoxide dismutase (MnSOD). (g) Caspase-3 activity. (h-k) Representative bands shown for Sirt3, TFAM, and NRF-2 proteins are provided. Mean ± SEM (n=12), P<0.05 vs WT+sham group; ^#P<0.05 vs Sirt3^−/− + sham group; ^§P < 0.05 vs MI/R group; P<0.05 vs Sirt3^−/−+MI/R group; ^&P<0.05 vs MI/R +DHM group.

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