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BioMed Research International
Volume 2019, Article ID 6932047, 11 pages
https://doi.org/10.1155/2019/6932047
Research Article

Juvenile Ovine Ex Vivo Larynges: Phonatory, Histologic, and Micro CT Based Anatomic Analyses

1Division for Phoniatrics and Pediatric Audiology, Department of Otorhinolaryngology, Head and Neck Surgery, Medical School, University Hospital, FAU Erlangen-Nürnberg, Waldstrasse 1, 91054 Erlangen, Germany
2Laboratory for Molecular Biology, Department of Otorhinolaryngology, Head and Neck Surgery, Medical School, University Hospital, FAU Erlangen-Nürnberg, Waldstrasse 1, 91054 Erlangen, Germany
3Division of Phoniatrics, ENT University Hospital Graz, Medical University Graz, Auenbruggerplatz 26, Graz 8036, Austria

Correspondence should be addressed to Michael Döllinger; ed.negnalre-ku@regnilleod.leahcim

Received 8 November 2018; Accepted 11 February 2019; Published 4 March 2019

Academic Editor: Jan Plzak

Copyright © 2019 Michael Döllinger et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Doellinger, “The next step in voice assessment: high-speed digital endoscopy and objective evaluation,” Current Bioinformatics, vol. 4, no. 2, pp. 101–111, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. V. Birk, M. Döllinger, A. Sutor et al., “Automated setup for ex vivo larynx experiments,” The Journal of the Acoustical Society of America, vol. 141, no. 3, pp. 1349–1359, 2017. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Ziethe, R. Patel, M. Kunduk, U. Eysholdt, and S. Graf, “Clinical analysis methods of voice disorders,” Current Bioinformatics, vol. 6, no. 3, pp. 270–285, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Semmler, S. Kniesburges, J. Parchent et al., “Endoscopic laser-based 3D imaging for functional voice diagnostics,” Applied Sciences, vol. 7, no. 6, p. 600, 2017. View at Publisher · View at Google Scholar
  5. B. Wong, R. P. Jackson, S. Guo et al., “In vivo optical coherence tomography of the human larynx: normative and benign pathology in 82 patients,” The Laryngoscope, vol. 115, no. 11, pp. 1904–1911, 2005. View at Google Scholar
  6. M. Klancnik, I. Gluncic, and D. Cikojevic, “The role of contact endoscopy in screening for premalignant laryngeal lesions: a study of 141 patients,” Ear, Nose & Throat Journal, vol. 93, no. 4-5, pp. 177–180, 2014. View at Google Scholar
  7. M. Gugatschka, J. C. Jarvis, J. D. Perkins et al., “Functional electrical stimulation leads to increased volume of the aged thyroarytenoid muscle,” The Laryngoscope, vol. 128, no. 12, pp. 2852–2857, 2018. View at Publisher · View at Google Scholar
  8. F. Alipour and S. Jaiswal, “Phonatory characteristics of excised pig, sheep, and cow larynges,” The Journal of the Acoustical Society of America, vol. 123, no. 6, pp. 4572–4581, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Gerstenberger, M. Döllinger, S. Kniesburges et al., “Phonation analysis combined with 3D reconstruction of the thyroarytenoid muscle in aged ovine ex vivo larynx models,” Journal of Voice, vol. 32, no. 5, pp. 517–524, 2018. View at Publisher · View at Google Scholar · View at Scopus
  10. R. W. Chan and I. R. Titze, “Effect of postmortem changes and freezing on the viscoelastic properties of vocal fold tissues,” Annals of Biomedical Engineering, vol. 31, no. 4, pp. 482–491, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. M. F. Regner, M. J. Robitaille, and J. J. Jiang, “Interspecies comparison of mucosal wave properties using high-speed digital imaging,” The Laryngoscope, vol. 120, no. 6, pp. 1188–1194, 2009. View at Google Scholar · View at Scopus
  12. V. Birk, S. Kniesburges, M. Semmler et al., “Influence of glottal closure on the phonatory process in ex vivo porcine larynges,” The Journal of the Acoustical Society of America, vol. 142, no. 4, pp. 2197–2207, 2017. View at Publisher · View at Google Scholar · View at Scopus
  13. V. Birk, A. Sutor, M. Döllinger, C. Bohr, and S. Kniesburges, “Acoustic impact of ventricular folds on phonation studied in ex vivo human larynx models,” Acta Acustica united with Acustica, vol. 102, no. 2, pp. 244–256, 2016. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Hillenbrand and R. A. Houde, “Acoustic correlates of breathy vocal quality: dysphonic voices and continuous speech,” Journal of Speech, Language, and Hearing Research, vol. 39, no. 2, pp. 311–321, 1996. View at Publisher · View at Google Scholar · View at Scopus
  15. X. Zheng, S. Bielamowicz, H. Luo, and R. Mittal, “A computational study of the effect of false vocal folds on glottal flow and vocal fold vibration during phonation,” Annals of Biomedical Engineering, vol. 37, no. 3, pp. 625–642, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. P. Vickerton, J. Jarvis, and N. Jeffery, “Concentration-dependent specimen shrinkage in iodine-enhanced microCT,” Journal of Anatomy, vol. 223, no. 2, pp. 185–193, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Mulisch and U. Welsch, Romeis—Mikroskopische Technik, Springer Spektrum, Heidelberg, Germany, 2010. View at Publisher · View at Google Scholar
  18. F. Alipour and S. Jaiswal, “Glottal airflow resistance in excised pig, sheep, and cow larynges,” Journal of Voice, vol. 23, no. 1, pp. 40–50, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. F. Alipour, E. M. Finnegan, and S. Jaiswal, “Phonatory characteristics of the excised human larynx in comparison to other species,” Journal of Voice, vol. 27, no. 4, pp. 441–447, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Döllinger, D. A. Berry, and S. Kniesburges, “Dynamic vocal fold parameters with changing adduction in ex-vivo hemilarynx experiments,” The Journal of the Acoustical Society of America, vol. 139, no. 5, pp. 2372–2385, 2016. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Döllinger, S. Kniesburges, D. A. Berry et al., “Investigation of phonatory characteristics using ex vivo rabbit larynges,” The Journal of the Acoustical Society of America, vol. 144, no. 1, pp. 142–152, 2018. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Schützenberger, M. Kunduk, M. Döllinger et al., “Laryngeal high-speed videoendoscopy: sensitivity of objective parameters towards recording frame rate,” BioMed Research International, vol. 2016, Article ID 4575437, 19 pages, 2016. View at Google Scholar · View at Scopus
  23. A. Boessenecker, D. A. Berry, J. Lohscheller, U. Eysholdt, and M. Doellinger, “Mucosal wave properties of a human vocal fold,” Acta Acustica united with Acustica, vol. 93, no. 5, pp. 815–823, 2007. View at Google Scholar · View at Scopus
  24. A. Branco, A. Todorovic Fabro, T. M. Gonçalves, and R. H. Garcia Martins, “Alterations in extracellular matrix composition in the aging larynx,” Otolaryngology—Head and Neck Surgery, vol. 152, no. 2, pp. 302–307, 2015. View at Publisher · View at Google Scholar
  25. T. Ohno, S. Hirano, and B. Rousseau, “Age-associated changes in the expression and deposition of vocal fold collagen and hyaluronan,” Annals of Otology, Rhinology & Laryngology, vol. 118, no. 10, pp. 735–741, 2009. View at Publisher · View at Google Scholar
  26. A. Lang, R. Koch, K. Rohn, and H. Gasse, “The histological components of the phoniatrical body-cover model in minipigs of different ages,” PLoS ONE, vol. 10, no. 5, Article ID e012808, 2015. View at Google Scholar · View at Scopus