BioMed Research International / 2019 / Article / Tab 3

Research Article

Functional Variant rs4442975 Modulating FOXA1 Binding Affinity Can Influence Bone Marrow Suppression during Neoadjuvant Chemotherapy for Luminal A Type Breast Cancer

Table 3

Association between rs4442975 and bone marrow suppression by NAC.

VariableBone marrow suppression
NoYesOR (95% CI);
N (%)N (%)

rs444297561105
TT37 (60.66)84 (80.00)1.00
GT22 (36.07)21 (20.00)0.39 (0.19–0.81); 0.011
GG2 (3.28)0
Dominant0.36 (0.17–0.73); 0.005
Additive0.38 (0.18–0.69); 0.003

and 95% CIs were calculated by unconditional logistic regression analysis after adjusting for age, smoking, alcohol use, and menopausal status.