Review Article
The Diagnostic Performance of Afirma Gene Expression Classifier for the Indeterminate Thyroid Nodules: A Meta-Analysis
Table 1
Summary of the studies’ characteristics included in the analysis.
| | First Author | Research Method | Center | Study Time | Site of GEC | Included Nodules |
| | Alexander et al.[7] | P | Multi Centers | 2011.1-2012.8 | Veracyte Inc | 567 | | Sacks et al.[12] | R | Single Center | 2012.1-2014.12 | tertiary | 567 | | Chaudhary et al.[13] | R | Single Center | 2009.7-2015.1 | Veracyte Inc | 158 | | Harrell et al.[14] | U | Single Center | 2011.1-2013.4 | Veracyte Inc | 58 | | Harrison et al.[15] | R | Single Center | 2013.8-2015.3 | Veracyte Inc | 115 | | El Hussein et al.[16] | R | Single Center | 2012.1-2016.7 | Veracyte Inc | 227 | | Abeykoon et al.[17] | R | Single Center | 2014.12-2015.2 | Veracyte Inc | 34 | | Noureldine et al.[18] | R | Single Center | 2012.1-2014.12 | Veracyte Inc | 273 | | McIver et al.[19] | P | Multi Centers | 2011.5-2012.12 | Veracyte Inc | 105 | | Marti et al.[20] | R | Multi Centers | 2013.2-2014.12 | Veracyte/tertiary | 165 | | Lastra et al.[21] | R | Single Center | 2011.2-2014.1 | Veracyte Inc | 132 | | Alexander et al.[22] | R | Multi Centers | 2010.9-2013.1 | Veracyte Inc | 339 | | Yang et al.[23] | R | Single Center | 2012.8-2014.4 | Veracyte Inc | 187 | | Celik et al.[24] | P | Single Center | 2011.12-2014.7 | Veracyte Inc | 66 | | Al-Qurayshi et al.[25] | R | Single Center | 2013.1-2016.2 | tertiary | 154 | | Samulski et al.[26] | R | Single Center | 2011.1-2015.12 | U | 294 | | Kay-Rivest et al.[27] | R | Multi Centers | 2013.?-2015.? | Veracyte Inc | 172 | | Han et al.[28] | R | Single Center | 2009.8-2013.3 | U | 114 |
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GEC, gene expression classifier; R: retrospective; P: prospective; U: unclear.
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