The Diagnostic Performance of Afirma Gene Expression Classifier for the Indeterminate Thyroid Nodules: A Meta-Analysis

Table 7

The metaregression of the test.

Model 1: the variables are method, site, center, and patients
Variable	Coefficient	Standard Error	p - value	RDOR	95%CI
Cte.	1.23	1.3157	0.3719	----	----
S	0.109	0.1715	0.5384	----	----
Method	-0.253	0.4549	0.5901	0.78	(0.28;2.14)
Site	-0.08	0.5308	0.8838	0.92	(0.28;3.01)
Center	0.594	0.8687	0.5096	1.81	(0.26;12.55)
Patients	0.001	0.0021	0.6037	1	(1.00;1.01)
Model 2: the variables are method, center, and patients
Variable	Coefficient	Standard Error	p - value	RDOR	95%CI
Cte.	1.09	0.9294	0.2655	----	----
S	0.127	0.1264	0.338	----	----
Method	-0.277	0.426	0.5289	0.76	(0.30;1.94)
Center	0.591	0.8685	0.51	1.81	(0.27;12.22)
Patients	0.001	0.0021	0.5692	1	(1.00;1.01)
Model 3: the variables are method and center
Variable	Coefficient	Standard Error	p - value	RDOR	95%CI
Cte.	1.295	0.8614	0.1586	----	----
S	0.122	0.1262	0.3527	----	----
Method	-0.257	0.4246	0.5569	0.77	(0.31;1.95)
Center	0.998	0.5232	0.0806	2.71	(0.87;8.48)
Model 4: the variable is center
Variable	Coefficient	Standard Error	p - value	RDOR	95%CI
Cte.	0.892	0.5458	0.126	----	----
S	0.11	0.1245	0.3949	----	----
Center	1.133	0.473	0.0323	3.11	(1.12;8.63)

RDOR: relative diagnostic odds ratios.