Neutrophilic Dermatoses and Their Implication in Pathophysiology of Asthma and Other Respiratory Comorbidities: A Narrative Review

Table 2

Major and minor criteria for the diagnosis of Sweet syndrome.

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Major Criteria

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(1) Clinically: sudden eruption of tender erythematous papules, coalescent plaques, or nodules commonly affecting face, neck, and the upper limbs
(2) Histologically: extensive dermal neutrophilic infiltrate and edema in the absence of leukocytoclastic vasculitis

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Minor Criteria

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(1) Fever > 38°C
(2) Preceded by vaccination or URTI or GIT infections, associated malignancy ( visceral or hematologic) or pregnancy
(3) Dramatic response to systemic steroids or potassium iodide
(4) Abnormal lab values at presentation (three of four): ESR >20 mm/hr; positive CRP; WBCs >8,000; >70% neutrophils)

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URTI: upper respiratory tract infections, GIT: gastrointestinal tract, ESR: erythrocyte sedimentation rate, CRP: C reactive protein, WBCs: white blood cells.